The pleiotropic benefits of statins

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Webb15 juni 2007 · Furthermore, at normal doses, statins inhibit cholesterol metabolism by macrophages and may lead to a reduction in macrophage activation and participation in atherogenesis. 18 In vitro immune modulating activities have also been demonstrated by some statins, including regulation of natural killer cell activity, and may be the basis of … Webb7 mars 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis Main. Atherosclerosis is a lipoprotein-driven, inflammatory process underlying heart attack and stroke and is …

The Pleiotropic Effects of Statins in Endocrine Disorders.

WebbOur study suggests that prior statin use, especially long-term lipophilic statin use, appears to confer preventive benefits against RA. Safety issues regarding the potential risk of … Webb9 nov. 2024 · Despite prior analyses suggesting that the cardiovascular benefits of statins are mediated mainly by the reduction in LDL-C (LDL cholesterol), 1 there has been ongoing debate as to whether the observed benefits and risks of statins are mediated exclusively via their LDL lowering properties or whether other pleiotropic mechanisms come into … fj cruiser baja roof rack

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Webb20 nov. 2024 · While not increasing the risk of bleeding, these pleiotropic antithrombotic effects may contribute to the overall cardiovascular benefits of statins and certain antihypertensive, antiarrhythmic and antidiabetic drugs. Clinicians and scientists may thus want to consider the ancillary effects in their daily practice and research. Webb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … Webb8 okt. 2015 · Thus, statins may modulate the function of cardiovascular cells and key signalling proteins, including small G-proteins, to ultimately exert their pleiotropic effects. Sphingosine-1-phosphate (S1P) is a naturally occurring bioactive lysophospholipid that regulates diverse physiological functions in a variety of different organ systems. cannot connect to destination host翻译

The Role of Statins in the Management of Heart Failure with …

Pleiotropic effects of statins - PMC - National Center for ...

WebbAlthough some trials evaluating the effects of statins on kidney disease outcomes have shown benefits of statins, 16,17,33 others have shown no effect. 18,34,35 However, most of these studies ... Dhawan V, Sharma PL, Kumar P. Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(7 ... WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins. cannot connect to destination host是什么意思WebbIndeed, recent studies indicate that some of the cholesterol-independent or “pleiotropic” effects of statins involve improving endothelial function, enhancing the stability of … fj cruiser battery borne

"WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Pharmaceutics Special Issue : Pleiotropic Effects of Statins

Webb12 feb. 2016 · Statin agents have been established as standard therapy for acute coronary syndrome (ACS) patients. The beneficial effects attribute to the pleiotropic actions of statin agents, of which low-density lipoprotein cholesterol (LDL-C) lowering effects are the most important. 10 But for ACS patients with low LDL-C level, statin therapy can benefit … Webb6 maj 2016 · These may be predicted as harmful or beneficial effects of the drug. The most wonderful positive pleiotropic effects of statins are anti-inflammatory, anti-proliferative, antithrombotic, improving endothelial dysfunction, and neuroprotective besides many others (Lewington et al. 2007; DuBroff and De Lorgeril 2015 ).

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WebbDespite the progressions in COVID-19 understanding, the optimization of patient-specific therapies remains a challenge. Statins, the most widely prescribed lipid-lowering drugs, … Webb7 apr. 2024 · Request PDF The pleiotropic effects of statins in rheumatoid arthritis Objectives: Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease. Studies over the past two decades ...

WebbSeveral aspects of the endocrine system have been shown to be influenced by the pleiotropic effects that statins exert, however, the benefits of statins on cardiovascular morbidity and mortality largely outweigh this deleterious effect, and statin therapy should continue to be recommended. BACKGROUND The 3-Hydroxy-3-MethylGlutaryl-CoA … Webb22 juli 2024 · As a result of their pleiotropic effects statins modulate virtually all known processes of atherosclerosis and have beneficial effects outside the cardiovascular …

Webb20 maj 2024 · One of the factors to be considered when evaluating outcomes of lipid-lowering treatment with statins is their solubility. Therefore, the role of both hydrophilic … WebbThe pleiotropic benefits of statins may result from their impact on vascular inflammation. The molecular process underlying this phenomenon is not fully elucidated. Here, RNA …

WebbIn RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk. Summary: The combined …

WebbInhibition of protein prenylation for proteins such as RhoA (and subsequent inhibition of Rho-associated protein kinase) may be involved, at least partially, in the improvement of endothelial function, modulation of immune function, and other pleiotropic cardiovascular benefits of statins, as well as in the fact that a number of other drugs that lower LDL … cannot connect to database server 오류Webb18 maj 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis ... Role of statin pleiotropism in acute coronary syndromes and stroke. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syn... cannot connect to azure storage accountWebb22 apr. 2024 · More than 35 million Americans take statins, most of whom are prescribed Atorvastatin being one of the most popular prescription drugs of its kind. Here are some of the many benefits of taking Atorvastatin medication for patients:. Taking Atorvastatin benefits the body’s cholesterol levels.; Atorvastatin works primarily by reducing low … fj cruiser beadlock wheels rimWebb1 feb. 2015 · The benefit of statins in the prevention of cardiovascular disease is well founded, derived from their lipid lowering and pleiotropic effects. The concept of lipoproteins as lipid transporters has evolved to encompass functions in coagulation, inflammation, and redox reactions due to their unique protein cargo. cannot connect to bluetooth on laptopWebb7 nov. 2024 · Ultimately, the benefits of statins in an infection setting appear to require attention to the underlying host response and to the timing of the dosage. From this examination of statin efficacy, additional novel host-directed strategies may produce adjunctive therapeutic approaches for the treatment of infection where traditional … fj cruiser bed platform plansWebbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF. fj cruiser bearing napaWebbThe cardiovascular risk benefits as well as the potential pleiotropic benefits of statins warrants strong consideration of use of statin therapy in patients with cirrhosis. Although 3-hydroxy-3-methyl-glutaryl-CoA reductase inhibitors (‘statins’) reduce the risk of cardiovascular events, fears about hepatotoxicity have historically led to underuse in … cannot connect to destination host什么意思