Tacc3 oocyte

Author: ecol

August undefined, 2024

WebMay 1, 2002 · D-TACC is also requiredto efficiently recruit Msps to the poles of the acentrosomal meiotic spindles in oocytes, suggesting that these proteins can work together to regulate microtubule behaviour even when centrosomes are not present [25. ... Thus, perhaps the TACC3 −/ ... WebTransforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes...

Q9Y6A5 - UniProt

WebTACC3; transforming acidic coiled-coil containing protein 3. Aliases: ERIC1, Tacc4, ERIC-1, maskin. Location: 4p16.3. Summary: This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may … WebNov 18, 2024 · We found that mutations in TACC3 cause defects in spindle assembly by disrupting the structure of the huoMTOC, which leads to clinical oocyte maturation arrest. This suggests that the huoMTOC might be an important biomarker for evaluating the … newport news health inspections

TACC3 increases the antagonizing activity of XMAP215

WebMar 1, 2024 · Spindle assembly defects mediated by centrin TACC3 and decreased acetylation, microﬁlament reorganization failure, and mitochondrial dysfunction were found to be the underlying mechanisms involved in the toxicity of cobalt chloride to oocytes. WebSep 19, 2005 · TACC3 enhances the number of microtubules emanating from mitotic centrosomes, and its targeting to centrosomes is regulated by Aurora A–dependent phosphorylation. We propose that Aurora A regulation of TACC3 activity defines a centrosome-specific mechanism for regulation of microtubule polymerization in mitosis. … WebApr 1, 2009 · TACC3 has a well characterized function in microtubule dynamics, particularly during mitosis, based on mutational analysis (see above) and physical interactions with Aurora A and Aurora B kinases, CKAP5 (ch-TOG/XMAP215) and AKAP9 via the TACC domain (see Peset and Vernos, 2008 for review). newport news greek festival 2021

TACC3 Is Important for Correct Progression of Meiosis in …

Tacc3 transforming, acidic coiled-coil containing protein 3

WebMar 1, 2024 · Cobalt chloride disrupted spindle formation by affecting TACC3 and decreasing Ac-a-tubulin levels, altered oocyte actin distribution and polarity, and impaired the mitochondrial structure and functions. The results provide in vivo evidence for cobalt chloride negatively affecting oocyte development. 2. Materials and methods 2.1. Chemicals WebMar 21, 2024 · TACC3 (Transforming Acidic Coiled-Coil Containing Protein 3) is a Protein Coding gene. Diseases associated with TACC3 include Gliosarcoma and Giant Cell Glioblastoma. Among its related pathways are Regulation of activated PAK-2p34 by … newport news greek festWebNational Center for Biotechnology Information intubated snake

"WebMay 1, 2024 · During mammalian oocyte development, two contrasting patterns of polyadenylation have been identified. ... SLBP (Abnova H00007884-M01, 200 ng/mL), tubulin (Sigma T8203, 10 μg/mL) and TACC3 ... " - Tacc3 oocyte

Tacc3 oocyte

TACC3 Is Important for Correct Progression of Meiosis in Bovine Oocytes …

WebJun 28, 2024 · ( A) Immunofluorescence images of mouse oocytes fixed at different times after nuclear envelope breakdown (NEBD). Gray, microtubules (α-tubulin); green, LISD (TACC3); magenta, aMTOCs (pericentrin). Insets are magnifications of regions outlined by … WebFeb 25, 2024 · Oocyte treatments with taxol, nocodazole, or cold did not affect CLTC expression levels but led to disorders of its distribution. Functional impairment of CLTC by specific morpholino injections in GV-stage oocytes led to disruptions in spindle assembly and chromosomal alignment, accompanied by impaired first polar body (PB1) emissions.

Did you know?

WebThe TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension ( PubMed: 21297582, PubMed: 23532825 ). May be involved in the control of cell growth and differentiation. May contribute to cancer ( PubMed: 14767476 ). By similarity 3 publications GO annotations Expand table Complete GO annotation on QuickGO Keywords WebOct 2, 2008 · TACC3 is an indirect target of TPX2 in the oocyte. A: Localization of P-TACC3 upon TPX2 depletion. Oocytes were triple labelled for P-TACC3 (red), microtubules (green) and nucleic acids (blue). P-TACC3 staining is absent in siTPX2-5h, siTPX2-5h co-injected …

WebJun 10, 2024 · TACC3, P16, and Ki-67 expression in HPVA and NHPVA. Next, we analyzed the expression profile of TACC3 in differenthistological subtypes of ECA. Additional file 5: Table S1 presents the clinicopathological data for the HPVA and NHPVA cases.By IHC, 64.0% of ECA samples and 36.0% of normal samples were positive for TACC3 in HPVA … WebThe expression levels of several microtubuleassociated proteins including TACC3, KIF14 and ASPM were also reduced in the aging oocytes. ... Proteomic analysis implicates that postovulatory...

WebTransforming acidic coiled-coil (TACC) proteins are key players during mitosis via stabilization of the spindle. The roles of TACCs during meiosis are however less clear. We used bovine oocytes... Webthat TACC3 is required for acentrosomal microtubule assembly (Fig. 1 C and D and Fig. S1 C and D). To understand why TACC3 is required for the acentrosomal microtubule aster assembly, we treated the mitotic HeLa cells with nocodazole or cold temperatures and observed that TACC3 stayed with the stable kinetochore-connectedﬁbers

WebSep 3, 2013 · TACC3 facilitates kinetochore–microtubule capture, interkinetochore tension, and spindle assembly checkpoint. Micrographs are presented as maximum intensity projections of different z sections. ( A) …

WebJul 13, 2015 · TACC3 mRNA was detected in bovine oocytes during meiosis using qRT-PCR, and while it was also expressed in cleavage stage embryos, its expression was down-regulated at the mor-ula and... newport news grissom libraryWebRecently, the human oocyte microtubule organizing center was found to be a driver for spindle assembly in human oocytes, and deficiencies in TACC3, the key component of this center, were shown to impair microtubule nucleation and meiotic spindle assembly, leading to nuclear maturation arrest . newport news gun rangeWebApr 26, 2024 · In summary, we conclude that AURKA is the only Aurora kinase in mouse oocytes that is essential for fertility and MI [ 30, 31] ( Fig 8 ). Its unique functions include, at least, initiating MTOC fragmentation through activation of PLK1 and spindle formation … newport news health and rehabWebJul 13, 2015 · TACC3 is expressed in oocytes and in early cleavage stage pre-implantation embryos. The expression of TACC3 mRNA in bovine oocytes and in vitro produced pre-implantation embryos was examined using qRT-PCR. TACC3 expression was detected at similar levels (p>0.05) throughout oocyte maturation and during the first cleavage stages … newport news halloween eventsWebJul 26, 2024 · TACC3 regulates spindle organization during mitosis and also regulates centrosome-mediated microtubule nucleation by affecting γ-Tubulin ring complexes. In addition, it interacts with different proteins (such as ch-TOG, clathrin and Aurora-A) to … intubated sedatedWebFeb 18, 2024 · 3.4 Oocyte and granulosa cell communications We used iTALK to characterize the L-R–mediated intercellular communication and list the top 100 L-R pairs in antral stage oocytes and GCs (Table S2 ). Figure 3A … newport news headlights cassieWebApr 3, 2024 · TACC3 is related to biological progress (BP), cellular component (CC), and molecular function (MF). ... Alzheimer disease, oocyte meiosis, phagosome, cell cycle, cellular senescence, DNA replication, and progesterone-mediated oocyte maturation. The 2 most negatively related categories included lysosome and human T cell leukemia virus 1 ... newport news golf course deer park