Polypyrimidine tract-binding-like protein
WebMay 30, 2000 · We have used the yeast two-hybrid system to isolate Nova interacting proteins and identify an RNA binding protein that is closely related to the polypyrimidine …
Polypyrimidine tract-binding-like protein
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Polypyrimidine tract-binding protein, also known as PTB or hnRNP I, is an RNA-binding protein. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization. Two 2024 studies have shown that depleting PTB mRNA in astrocytes … See more • Polypyrimidine tract See more • polypyrimidine+tract-binding+protein at the US National Library of Medicine Medical Subject Headings (MeSH) See more WebSep 8, 2008 · The polypyrimidine tract binding protein, PTBP2, is an RNA-binding protein that splices nuclear transcripts and stabilizes specific mRNAs in the cytoplasm. The mechanisms whereby MSY2 selects and stabilizes a large group of male germ cell mRNAs and PTBP2 stabilizes specific mRNAs such as the phosphoglycerate kinase 2 mRNA in …
WebThe production of illegitimately transcribed mRNA from peripheral blood leukocytes and its use for mutational analysis of many tissue‐specific genes has been known for 15 years [1]. Two recent publications in this journal by Green et al. and Cutler et al. [2,3] have, however, highlighted the difficulty in using ‘illegitimate’ transcripts of factor FIX mRNA isolated … WebInterestingly, the polypyrimidine strand of the repeat (CTC) bound other proteins such as polypyrimidine tract-binding protein 1 (PTBP1) as single-stranded (SS) DNA, and a model with two alternative DNA conformations is proposed for these repeats. Distinct protein binding to DS DNA was also observed for different numbers of AAACA and AAAAT repeats.
WebJul 25, 2024 · Scientific leader with expertise in biophysics, protein biochemistry, and structural biology. Experience managing direct reports as well as CRO based research in the areas of structural biology ... WebMar 27, 2024 · Polypyrimidine tract binding protein (PTB) is a major hnRNP protein with multiple roles in mRNA metabolism, including regulation of alternative splicing and internal ribosome entry site-driven tran...
WebHere it is shown that the Apaf-1 IRES is active in rabbit reticulocyte lysates, provided that the system is supplemented with polypyrimidine tract binding protein (PTB) and upstream of N-ras (unr), two cellular RNA binding proteins previously …
WebSeveral studies figure out TNF-α stimulates NF-κB in cancer cells like A549 and increases the ability of TGF-β1 to induce EMT. 28 Here, ... Liang X, Shi H, Yang L, et al. Inhibition of polypyrimidine tract-binding protein 3 induces apoptosis and cell cycle arrest, and enhances the cytotoxicity of 5-fluorouracil in gastric cancer cells. philips healthcare alice nightoneWebHuR and polypyrimidine tract binding protein (PTB) have been described as 'global regulators' of RNA alternative splicing, stability, and translation in non-neuronal (including ectodermal) tissues examined to date in diverse species, and REST/NRSF (RE-1 … philips healthcare alpharettaWebPolypyrimidine tract-binding protein (PTB), as a member of the heterogeneous nuclear ribonucleoprotein family, functions by rapidly shuttling between the nucleus and the … philips headphones wireless shd8850/79WebThe RNA-binding motif 4 (RBM4) protein participates in cell differentiation via its role in regulating the expression of ... (7/8), whereas its antagonist polypyrimidine tract-binding protein 1 (PTBP1) acted in an opposite manner. RBM4 directly ... NPEVs are associated with epidemics-like outbreaks during which they are detected ... philips healthcare analyticsWebSep 30, 1997 · Polypyrimidine tract binding protein (PTB) is a 57 kD hnRNP protein (hnRNP I) that binds to the pyrimidine tract typically found near the 3‘ end of introns. Primary sequence analysis suggests that PTB contains four RNA recognition motifs (RRMs). Data from comparative structural and deletional analysis of PTB are consistent with the … philips healthcare 13943bWebAug 23, 2024 · Metabolic and proliferative state of vascular adventitial fibroblasts in pulmonary hypertension is regulated through a MicroRNA-124/PTBP1 (polypyrimidine tract binding protein 1)/pyruvate kinase muscle axis. Circulation. 2024; 136:2468–2485. doi: 10.1161/CIRCULATIONAHA.117.028069 Link Google Scholar; 8. philips healthcare 10kWebThe polypyrimidine tract is a region of pre-messenger RNA (mRNA) that promotes the assembly of the spliceosome, the protein complex specialized for carrying out RNA … philips healthcare 3000 minuteman road