High affinity copper uptake protein 1
WebProperties of nanobodies. A) The antigen binding regions of a conventional antibody, known as the variable domains, are located on both the heavy chains (V H domains) and light chains (V L domains) adjacent to the constant regions C H 1-3 and C L.In camelid heavy-chain-only antibodies (e.g., from alpacas), there is a single variable domain on each … Web30 de mar. de 2024 · Functional assays revealed that it stimulates the initial rate of radiolabeled copper uptake. CTR1 transports copper with high affinity in a time-dependent and saturable manner and is copper-specific. Transport is an energy-independent process and is stimulated by extracellular acidic pH and high K+ …
High affinity copper uptake protein 1
Did you know?
WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … WebAntigen: High affinity copper uptake protein 1 Available to For-Profits: Yes Antigen Species: Human Hybridoma Cells Available (Non-Profit): No Isotype: MIgG2b Depositor: Clinical Proteomics Technologies for Cancer Host Species: mouse Antigen Sequence: Positive Tested Species Reactivity: Human Depositors Institution: National Cancer Institute
Web8 de jul. de 1997 · We propose this gene as a candidate for high-affinity copper uptake in humans and by analogy have named it h CTR1. The hCTR1 and yeast CTR1 predicted transmembrane proteins are 29% identical, but the human protein is substantially smaller in both the extracellular metal-binding and intracellular domains. Web1 de mar. de 2024 · Cu homeostasis is maintained by many chaperone proteins and transport carriers (Kim et al., 2008 ). For example, high affinity copper uptake protein 1 (CTR1) is a high-affinity Cu transporter which is located on cell membranes to uptake extracellular Cu ions ( Lee et al., 2002 ).
Web149 Likes, 9 Comments - Joshua Rubin (@realfoodgangstas) on Instagram: "10 Things You Can Do Today to Replenish Zinc Status to Support Thyroid Health Lets talk about ... http://www.cloud-clone.com/products/MAE493Hu21.html
Web1 de abr. de 2002 · Copper uptake High-affinity copper transport proteins Physiological and biochemical studies many years ago suggested the presence of at least two independent activities responsible for copper uptake in eukaryotic cells, of distinct affinities and capacities for copper [6].
Web27 de abr. de 2024 · Multicopper oxidases (MCOs) are blue copper containing proteins and they generally have multiple copper atoms (1 to 6) per molecule [1,2]. ... Structural analysis shows that Fet3p belongs to the family of integral membrane protein (type 1). ... (high affinity iron uptake; 70% similarity with ScFET3), CgFET4 (low-affinity ferrous ... five bulb bathroom light coverWebIn normal intestinal epithelial cells (left), copper (Cu) [depicted as brown circles] is mainly imported via the high-affinity transporter CTR1. Intracellular Cu is then transported to the mitochondria and the trans-Golgi network (TGN), where it … five bulb bathroom light cover onlyWebHMDBP08240. Secondary Accession Numbers. 13952. Name. High affinity copper uptake protein 1. Synonyms. Copper transporter 1. Solute carrier family 31 member 1. hCTR1. canine skin condition with fowl odorWeb19 de out. de 2024 · HD is a neurodegenerative disorder, caused by a dominant polyglutamine expansion within the N-terminus of the huntingtin protein and is characterized by oxidative stress and striatal degeneration. 63 In the striatum of HD brains, high Cu and iron concentrations have been detected. 64 Studies by Fox and colleagues (2007) have … canine skin conditions picturesWebCTR1 undergoes MAC1-dependent degradation at the membrane in cells exposed to high copper levels and in a fashion independent of endocytosis. Present with 1180 molecules/cell in log phase SD medium. Catalytic activity Cu2+(in) = Cu2+(out) 2 publications This reaction proceeds in the backward direction. Source: Rhea 28703 Hide … canine skin conditions treatmentWeb1 de abr. de 2024 · The CTR1 gene of Saccharomyces cerevisiae encodes a protein required for high affinity copper uptake. The protein is expressed on the plasma membrane, is heavily glycosylated with O-linkages, and ... canine skin diseases picturesWebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily … canine skin disorders photos