Web27 de fev. de 2024 · Mitochondria play a vital role in ferroptosis induced by cysteine deprivation but not by glutathione peroxidase-4 (GPX4) inhibition, the most downstream … WebDDD promotes the production of HIF-1 protein by inhibiting the degradation of HIF-1α, and inducing HIF-1α binding HIF-1β to activate HIF-1 signaling pathway which attenuated mitochondrial damage, improved mitochondrial function, inhibited the production of ROS, suppressed the occurrence of lipid peroxidation, upregulated the expression of GPX4 …
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Web14 de abr. de 2024 · For primary antibodies, we used TfR (10084-2-AP, 1:1000, proteintech), GPX4 ... of exosomal components and recognized miR-21 from BECs as a mediator of myofibroblast differentiation by pVHL/HIF ... Web4 de mar. de 2024 · In conclusion, our findings indicated that ferroptosis plays a crucial role in the development of ATB-DILI. Furthermore, anti-TB drug-induced hepatocyte ferroptosis was shown to be regulated by HIF-1α/SLC7A11/GPx4 signaling. These findings shed new light on the mechanisms underlying ATB-DILI and suggest novel therapeutic strategies … greenlife cookware coupon
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Web5 de jan. de 2024 · Trabectedin upregulated iron, ROS, and lipid peroxidation in NSCLC cells, causing ferroptosis. Trabectedin increases iron and ROS levels by upregulating … WebGPX4 and SLC7A11 immunostaining signals were obviously observed in HSCs around the fibrotic scars induced by CCl 4, whereas sorafenib treatment reduced GPX4 and … Web12 de abr. de 2024 · Amino acid metabolism pathway can regulate the synthesis of glutathione (GSH) and promote glutathione peroxidase 4 (GPX4) to play antioxidant protective role, which can remove reactive oxygen species (ROS), ultimately inhibiting ferroptosis. 6 Reduced GSH can cause impaired GPX4-mediated ROS clearance, … green life cookware chicken fryer