Greatwall phase 3
WebSep 1, 2013 · Recently, a serine/threonine kinase, Greatwall (GWL), has been identified as a mitotic regulator that inhibits PP2A activity [11– 13]. Depletion of GWL from interphase prevents entry into M phase, whereas overexpression of GWL accelerates entry into M phase in several species, including Drosophila, Xenopus, and human [11– 17]. http://kenyalaw.org/caselaw/cases/view/253708/index.html
Greatwall phase 3
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WebOct 24, 2024 · Greatwall (Gwl, known as Mastl in mammals, Rim15 in budding yeast and Ppk18 in fission yeast) is a member of the AGC family of kinases (Blake-Hodek et al., … WebMar 20, 2024 · The atypical AGC kinase Greatwall (Gwl) mediates a pathway that prevents the precocious removal of phosphorylations added to target proteins by M phase-promoting factor (MPF); Gwl is thus essential for M phase entry and maintenance. Gwl itself is activated by M phase-specific phosphorylations that are investigated here.
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