Gata2 transcription factor

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August undefined, 2024

WebGATA2 → Endothelial transcription factor GATA-2. Protein also known as : GATA-binding protein 2 . Gene name : GATA2. Entry whose protein (s) existence is based on evidence at protein level. Show evidences. Annotations in this section apply to all the isoforms if not specified otherwise. WebMar 21, 2024 · GATA2 is a transcription factor involved in stem cell maintenance with key roles in hematopoietic development. GATA2 mutations are associated with a variety of inherited and acquired …

Transcription Factor GATA 2 - an overview ScienceDirect Topics

WebJan 21, 2024 · Our studies reveal that GATA2 promotes robust gene transcription to maintain mast cell identity and respond to antigenic stimulation by binding to super-enhancer regions with dense GATA2... WebJun 1, 2006 · Here, we report several lines of data supporting the involvement of GATA2,a transcription factor that contains two C4 zinc fingers, in such crosstalk. GATA2 was … chemical engineering in pakistan

The transcription factor complex LMO2/TAL1 regulates branching …

WebThe GATA2 transcription factor contains two zinc finger (i.e. ZnF) motifs. C-ZnF is located toward the protein's C-terminus and is responsible for binding to specific DNA sites. N-ZnF is located toward the proteins N-terminus and is responsible for interacting with various other nuclear proteins that regulate its activity. WebOct 25, 2024 · The earliest cell fate commitment event that takes place during eutherian embryogenesis is the bifurcation of totipotent cells into the inner cell mass that generates … WebMar 20, 2024 · Monocytopoiesis involves the stepwise differentiation in the bone marrow (BM) of common myeloid precursors (CMPs) to monocytes. The basic helix-loop-helix … flight 6312

The role of GATA2 in lethal prostate cancer aggressiveness

GATA2 Gene - GeneCards GATA2 Protein GATA2 Antibody

WebGATA1 is a transcription factor critical for normal megakaryocytopoiesis, and several different causative mutations have been identified within the region encoding its N-terminal zinc finger domain.175,176 From: Consultative Hemostasis and Thrombosis (Third Edition), 2013 Add to Mendeley About this page WebOct 25, 2024 · We found that a network of the transcription factors GATA2, GATA3, TFAP2A, and TFAP2C regulates early trophoblast progenitor specification by activating placental genes and inhibiting the pluripotency gene OCT4, thus acting to couple trophoblast specification with exit from pluripotency. chemical engineering intern 2023 singaporeWebApr 19, 2005 · GATA2 transcription factor is an inhibitor of adipogenesis and an activator of vascular cells. We hypothesized that GATA2 activity is controlled by insulin during adipogenesis, linking metabolic homeostasis and inflammation. Methods and Results— We show that insulin induces GATA2 phosphorylation on serine 401 in a PI … chemical engineering inservice training

"WebApr 13, 2024 · GATA-1-mediated replacement of GATA-2 represses Gata2 transcription during erythroid maturation via FOG-1- and SetD8-dependent mechanisms. 65 GATA switching occurs at 5 highly conserved Gata2 sites, −77, −3.9, −2.8, −1.8, and +9.5 kb relative to the 1S promoter. 28, 56, 57, 64 As GATA-2 and GATA-1 occupy these sites at … " - Gata2 transcription factor

Gata2 transcription factor

GATA2 deficiency: a protean disorder of hematopoiesis, …

WebGATA2 (located at 3q21.3) is an early hematopoietic transcription factor most active in myeloid development. 47 The syndrome of monocytopenia and mycobacterial disease (monoMAC) is characterized by late childhood or adult-onset disseminated nontuberculous mycobacterial disease or disseminated fungal disease. WebMay 4, 2024 · Vascular endothelial growth factor (VEGF)-A is a major proangiogenic chemoattractant and mitogen that is secreted from hypoxic sites and that binds to VEGF …

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WebDec 2, 2013 · The Gata2 transcription factor is expressed in the mouse embryo in a pattern consistent with a role in hematopoietic cell development (Minegishi et al., 1999; Robert-Moreno et al., 2005). It is first expressed at E7.5 in the primitive streak and the endothelial cells of the paired dorsal aorta. WebDevelopmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis Br J Haematol. 2002 Nov;119(2) :510-5. doi ... GATA2 Transcription Factor GATA2 …

WebFeb 1, 2024 · Downstream of GATA-2 expression, GATA-2–regulated genetic networks are highly context-dependent ( 12, 28, 29, 50, 51 ), involving variable composition and activity of coregulators and transcription factors within distinct cell types and even subnuclear domains within a single cell type. WebSep 22, 2024 · After discovery of the founding member of the GATA transcription factor family GATA1, 1,2 GATA2 was shown by Orkin and colleagues in 1994 to be a vital determinant of multilineage …

WebThe gene promoter is a complex area containing numerous binding sites for transcription factors, which determines the transcription start site and frequency [25]. ... SP1, GATA2, NFIC, and other transcription factor-binding sites. MZF1, a member of the C2H2-type zinc finger protein family, is involved in the proliferation and differentiation of ... Web该GATA2 Polyclonal Antibody. This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they …

WebFeb 6, 2014 · GATA2 deficiency has a broad phenotype encompassing immunodeficiency, MDS/AML, pulmonary disease, and vascular/lymphatic dysfunction. Early genetic diagnosis is critical to direct clinical management, prophylaxis, …

WebEnter the email address you signed up with and we'll email you a reset link. chemical engineering internWebMar 20, 2024 · Monocytopoiesis involves the stepwise differentiation in the bone marrow (BM) of common myeloid precursors (CMPs) to monocytes. The basic helix-loop-helix transcription factor TAL1/SCL plays a critical role in other hematopoietic lineages, and while it had been reported to be expressed by BM-derived macrophages, its role in … chemical engineering in psg collegeWeb2 days ago · The early transcription factor GATA-2 is expressed in classical Hodgkin’s lymphoma. The Journal of Pathology, 204(5), 538–545. doi:10.1002/path.1664 … chemical engineering in sasolWeb启动子，促进gata2表达，gata2一方面直接调控高亲和力 IgE受体（FcεRI）、c-kit蛋白、组胺及IL-4的水平，另一方面促进C/EBPα和MITF的表达从而来调控终 ... flight 631 january 25 tampaWebGATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. These genes are located on the X chromosome in both … chemical engineering inservice training 2022WebThe master regulatory transcription factor GATA-2 triggers hematopoietic stem and progenitor cell generation. GATA2 haploinsufficiency is … flight 632WebJun 1, 2006 · Here, we report several lines of data supporting the involvement of GATA2,a transcription factor that contains two C4 zinc fingers, in such crosstalk. GATA2 was first described as a regulatory protein that plays a major role in the proliferation of progenitors and in lineage specification during early hematopoiesis. flight 630 to denver