Cisplatin renal clearance

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August undefined, 2024

WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated... WebSep 1, 2014 · Overexpression of Sirt1, a NAD-dependent protein deacetylase, in the proximal tubule cell maintains peroxisome number and reduces renal reactive oxygen species levels which rescued cell apoptosis induced by cisplatin . Downregulation of Klotho gene, an anti-aging gene expressed in the distal convoluted tubules, was observed in …

Cisplatin dose adjustment in patients with renal …

WebHowever, on day 5 of treatment patients showed increased alpha-half life and AUC of plasma Pt, as well as decreased Pt total body clearance and Pt renal clearance, associated to a significant (although still within normal range) increase in serum creatinine and a decrease in urinary volume. WebMar 2, 2024 · After several decades, cisplatin continues to be an essential drug for the treatment of several tumors, however, its potential nephrotoxicity is still a clinically relevant issue. Identification of predisposing factors for renal toxicity could be of value to warrant prophylactic measures. We analyzed data from 198 patients with various tumor types, … how many chinese live in mexico

International Society of Geriatric Oncology (SIOG) …

WebRenal function of cancer patients "fit" for Cisplatin chemotherapy: physician perspective Authors J Montoya 1 , H G Luna 2 , J R Amparo 2 , C Casasola 3 , G Cristal-Luna 2 Affiliations 1 Joey Montoya, MD, National Kidney and Transplant Institute, Philippines. WebApr 12, 2024 · OCT2 exerts its action through cisplatin transport into renal tubular epithelial cells . Consequently, OCT2 is responsible for the cellular uptake of cisplatin and, thus, for its intracellular accumulation. ... Indeed, from 5% to 15% of the patients with both estimated creatinine clearance (eCrCl), expressed in milliliters/minute, ... WebFeb 16, 2016 · We consider creatinine clearance a more accurate indicator than serum creatinine levels as it takes bodyweight into account. Nephrotoxicity during CCRT (Glomerular Filtration Rate [GFR] <50 mL/min) may require cisplatin dose reductions. This in turn, however, may lead to poorer treatment outcomes. high school lunch cook off korean show

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Evaluation of nephroprotective effects of persea americana on cisplatin …

WebRenal clearance is most commonly a feature of polar, low LogD 7.4 (<~1) ... Renal clearance accounts for more than 90% of the clearance of platinum agents.[47] … WebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data … how many chinese live in chinaWebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m2 following administration of 100 mg/m2 as 2-hour or 6- to 7-hour infusions, … how many chinese consulates in usa

"WebThe intraperitoneal injection of cisplatin increased kidney weight, serum cystatin-c, and serum creatinine, at the same time, decreased body weight, urinary volume, urine creatinine, creatinine clearance, and renal antioxidant activity, all of which were significant. " - Cisplatin renal clearance

Cisplatin renal clearance

Evaluation of nephroprotective effects of persea americana on cisplatin …

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute kidney disease, whereas the mechanism of chronic kidney disease after cisplatin chemotherapy is largely unknown. In the present study, … WebJan 7, 2024 · Most patients had oropharyngeal cancer, 35 patients in the mannitol group and 26 patients in the non-mannitol group. All patients were Caucasian. After the third series of cisplatin, the mean value of 51 Cr-EDTA clearance had declined to 92.3 mL/min (23.1) in the non-mannitol group and to 96.4 mL/min (20.8) in the mannitol group. The ...

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WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and ovaries (Metastatic Ovarian Carcinoma). Cisplatin may be … WebSep 21, 2016 · Purpose Efficacy of formulas calculating creatinine clearance (CrCl) to determine renal function eligibility (CrCl > 60 mL/min) for cisplatin-based chemotherapy has not been examined adequately in the bladder cancer population. We hypothesize these formulas may underestimate measured CrCl, and therefore the eligibility for cisplatin …

WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose … WebThe clearance (or total clearance) of a drug is the sum of the clearances of the eliminating organs, mainly the kidneys and the liver: CL = CL renal+CL hepatic. The hepatic clearance tends to be lower in elderly than in younger patients but that is …

WebSep 16, 2024 · The mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m 2 following administration of 100 mg/m 2 as 2-hour or 6- to 7-hour infusions, respectively. The renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing ... WebPhase Ib/II Study of Neoadjuvant Pembrolizumab With Gemcitabine-Cisplatin (Cisplatin-Eligible) or Gemcitabine (Cisplatin-Ineligible) in Subjects With T2-4aN0M0 Urothelial Cancer: HCRN GU14-188 ... Renal: Measured or calculated creatinine clearance ≥30 mL/min; ... Glomerular filtration rate (GFR) or creatinine clearance (Ccr) ≥ 50 mL/min ...

WebPretreatment with cisplatin has been reported to increase MTX toxicity, possibly by decreasing renal clearance (40). AKI prolongs extrarenal toxicity (myelosuppression …

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this ... in the nephrotoxicity caused by cisplatin. 3,18,20 These previous reports also elucidated the association between the clearance of cationic drugs and the toxicity of ... how many chinese miners came to australiaWebSerum creatinine, blood urea nitrogen, electrolyte, and glomerular filtration rate (GFR) were measured at baseline and days 2 and 7. Moreover, GFR was calculated based on the 24-hour urine creatinine clearance rate to assess renal function at baseline and 48 hours after receiving cisplatin. high school lunchboxesWebcisplatin increases levels of paclitaxel by decreasing renal clearance. Minor/Significance Unknown. conivaptan. conivaptan will increase the level or effect of paclitaxel by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. cortisone. how many chinese military personnelWebBackground A strategy for preventing cisplatin nephrotoxicity due to enhanced oxidative stress and inflammatory response is highly desirable. Thioredoxin-1 (Trx), an endogenous redox-active protein, high school lunch menu for 2018 calumetWebJun 8, 2024 · The renal clearance of free platinum is nonlinear and variable and is dependent on dose, urine flow rate, and individual variability in the extent of active … high school lunch menu/corrypaWeb• Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Ensure adequate hydration. Consider dose reductions or alternative treatments in … high school lycéeWebThe renal clearance of free (ultrafilterable) platinum also exceeds the glomerular filtration rate indicating that cisplatin or other platinum-containing molecules are … how many chinese nuclear subs