Calsyntenin-1
WebJun 7, 2006 · Calsyntenin-1 Is Enriched in Axonal Growth Cone Vesicles. The presence of calsyntenin-1–containing organelles in developing axons led us to presume that these … WebNov 9, 2024 · Calsyntenin-1 (CLSTN1), a type I transmembrane protein, is a member of the cadherin superfamily of cell-adhesion molecules. Although the brain displays the highest levels of expression, CLSTN1 can also be …
Calsyntenin-1
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WebAug 1, 2016 · Calsyntenin-1 has previously been shown to mediate transport of endosomes along microtubules in neurons, through interactions with kinesin light chain-1. Here we demonstrate for the first time, we believe, a similar role for calsyntenin-1 in Huh7 cells, mediating intracellular transport of endosomes. In HCV-infected cells we show that ... WebCalsyntenin-1 (CST-1; gene name CLSTN1), also called Alcadein-alpha, is a 140‑150 kDa type I transmembrane glycoprotein that is member of the Alcadein family of cadherin …
WebJul 14, 2015 · Thus a common structure affected in all calsyntenin-deficient mice is the synapse, although different synapse types are involved, with calsyntenin-1 loss affecting excitatory synapses (Ster et al ... WebJul 1, 2012 · Calsyntenin-1 is a ligand for kinesin-1 light chains and APP is transported through axons on kinesin-1 molecular motors. Defects in axonal transport are an early …
WebSep 22, 2024 · Calsyntenin-1 mediates hepatitis C virus replication. Awan Z, Tay ESE, Eyre NS, Wu LE, Beard MR, Boo I, Drummer HE, George J, Douglas MWAwan Z, et al. J Gen Virol, 2016 Aug. PMID 27221318; Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease. WebRayBio® Human Immunoquantitative (PCR-Based) Calsyntenin-1 ELISA Kit for cell culture supernatants, plasma, and serum samples. 7 week lead time
WebAug 15, 2012 · Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, …
WebThe calsyntenin-1 is located in the postsynaptic membrane of CNS synapses and a proteolytically processed protein of the postsynaptic membrane with a calcium-binding cytoplasmic domain. Calsyntenin-1 is a dynamic modulator of postsynaptic calcium by extracellular proteolysis. Calsyntenin-1 may modulate Ca2+ transients locally either … mid 5 employment harrisburg ilWebDec 31, 2024 · Calsyntenin-1 directly correlated with global pathological tau burden in FTLD (r 2 =.22; p=0.005) and in “pure FTLD” (r 2 =.17; p=0.02). Conclusion Low CSF levels of the post-synaptic modulator, Calsyntenin-1, is specific to FTLD, particularly in cases with little or no tau pathology and could aid the early diagnosis of FTD and the ... mid 60 visitors cover bupaWebMay 1, 2024 · Adipose-specific ablation of lysine-specific demethylase 1 (Lsd1, also known as Kdm1a) has previously been found to cause severe BAT dysfunction 13.Expression of calsyntenin 3 (Clstn3) is strongly ... mid 63a1f33d6a2969bcd95943a4WebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However, its neuronal function during postnatal development remains unknown. We generated a knock-out mouse to characterize … new smyrna coconut palms beach resortWebCalsyntenin-1 is a neuronally enriched type-1 membrane-spanning protein that binds directly to KLCs via its intracellular C-terminal domain (13–16). As such, calsyntenin-1 acts as a ligand to mediate transport of a subset of vesicles through axons on kinesin-1 motors. A proportion of APP and calsyntenin-1 co-localize in cells and tissues, and ... mid 60s bridal gownsWebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is … mid626k2 new balanceWebNov 9, 2024 · Calsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of … mid7540371a1 yardman belt mower